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Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation

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Matos, Carina ; Mamilos, Andreas ; Shah, Pranali N. ; Meedt, Elisabeth ; Weber, Daniela ; Ghimire, Saroj ; Hiergeist, Andreas ; Gessner, André ; Dickinson, Anne M. ; Dressel, Ralf ; Walter, Lutz ; Stark, Klaus J. ; Heid, Iris M. ; Poeck, Hendrik ; Edinger, Matthias ; Wolff, Daniel ; Herr, Wolfgang ; Holler, Ernst ; Kreutz, Marina ; Ghimire, Sakhila
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Date of publication of this fulltext: 31 Oct 2022 08:33


The vitamin D receptor (VDR) is critical in regulating intestinal homeostasis and emerging evidence demonstrates that VDR deficiency is a critical factor in inflammatory bowel disease pathology. However, no clinical data exist regarding the intestinal expression of VDR in patients after allogeneic haematopoietic stem cell transplantation (HSCT). Analyzing intestinal biopsies from 90 patients ...


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