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Comparison of ultrafiltration and microdialysis for ceftriaxone protein-binding determination

Sanz-Codina, Maria ; Wicha, Sebastian G ; Wulkersdorfer, Beatrix ; Al Jalali, Valentin ; Van Os, Wisse ; Vossen, Matthias G ; Bauer, Martin ; Lackner, Edith ; Dorn, Christoph ; Zeitlinger, Markus


Objectives: This clinical study compared in vitro ultrafiltration (UF) and in vivo IV microdialysis (MD) methods to determine ceftriaxone PB. Methods: Six healthy male volunteers received a single IV 2 g dose of ceftriaxone. Unbound ceftriaxone plasma concentrations were measured with MD and venous plasma sampling with subsequent UF. Pharmacokinetic parameters were determined using ...


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