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Picolinic Acids as Inhibitors of Dopamine b-Monooxygenase: QSAR and Putative Binding Site

Dove, Stefan



Abstract

Dopamine b-monooxygenase (DBM, EC 1.14.17.1) catalyzes the oxidn. of dopamine into (R)-noradrenaline. DBM inhibitors may act as antihypertensive drugs. A series of 22 picolinic acids substituted in 4- and 5-position was previously synthesized and tested for inhibition of DBM from bovine adrenal medulla. The QSAR of these compds. were investigated by Hansch anal. and comparative mol. field ...

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