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Model-based LFER parameters and QSAR of ligand-ß-adrenoceptor interactions. I. Equilibrium models and parameters of ß-adrenergic effectuation

Dove, Stefan ; Franke, R.



Abstract

A sep. consideration of ligand-b-adrenoceptor interactions responsible for affinity (recognition, binding) and agonistic activity, resp., is very important for the explanation of mol. events eliciting the activating conformational change of the receptor. Equil. models of b-adrenergic effectuation including receptor activation by agonists and partial agonists, receptor-effector (G-protein) ...

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