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QSAR in DBH-Blocking and Hypotensive Fusaric Acid Derivatives

Dove, Stefan ; Franke, R. ; Oehme, P. Kuchar, M. , eds.



Abstract

Twenty-two fusaric acid derivs. (I; R2 = H, OMe, OEt, Cl, or NO2; R1 = H, halo, alkyl, O-alkyl, CO2H, etc.) and picolinic acid [98-98-6] were tested for dopamine b-hydroxylase (DBH) [9013-38-1] inhibition in vitro as well as for their effects on blood pressure in rats; QSAR of this data was carried out using the Hansch approach. QSARs of DBH inhibition differed with the enzyme prepn. (Cu2+ ...

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