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Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

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Greppmair, Sebastian ; Brinkmann, Alexander ; Roehr, Anka ; Frey, Otto ; Hagel, Stefan ; Dorn, Christoph ; Marsot, Amélie ; El-Haffaf, Ibrahim ; Zoller, Michael ; Saller, Thomas ; Zander, Johannes ; Schatz, Lea Marie ; Scharf, Christina ; Briegel, Josef ; Minichmayr, Iris K. ; Wicha, Sebastian G. ; Liebchen, Uwe
Date of publication of this fulltext: 20 Jul 2023 07:38


Purpose: Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising to individualize dosing; however, the transferability of published models to external populations is uncertain. This study aimed to externally evaluate the available PIP population pharmacokinetic (PopPK) models. Methods: ...


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