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Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative

Gust, Ronald ; Schnurr, Beate ; Krauser, Rudolf ; Bernhardt, Günther ; Koch, Marion ; Schmid, Beate ; Hummel, Evelyn ; Schönenberger, Helmut



Abstract

The synthesis of the diastereomeric [1,2-bis(4-fluorophenyl)ethylendiamine][cyclobutane-1,1-dicarboxylato]platinum(II) complexes, rac- and meso-4F-Pt(CBDC), the evaluation of their structures, their tumor-inhibiting properties and their stability in physiol. environment were described (ref. complexes: the dichloro- and sulfatoplatinum(II) analogs, carboplatin and cisplatin). Rac-4F-Pt(CBDC) ...

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