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Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative

Gust, Ronald, Schnurr, Beate, Krauser, Rudolf, Bernhardt, Günther, Koch, Marion, Schmid, Beate, Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

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Abstract

The synthesis of the diastereomeric [1,2-bis(4-fluorophenyl)ethylendiamine][cyclobutane-1,1-dicarboxylato]platinum(II) complexes, rac- and meso-4F-Pt(CBDC), the evaluation of their structures, their tumor-inhibiting properties and their stability in physiol. environment were described (ref. complexes: the dichloro- and sulfatoplatinum(II) analogs, carboplatin and cisplatin). Rac-4F-Pt(CBDC) ...

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Item type:Article
Date:1998
Additional Information (public):CAN 130:90198 1-6 Pharmacology 184895-28-1P; 185069-09-4P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) ([rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin deriv., antitumor effect); 5445-51-2 (1,1-Cyclobutanedicarboxylic acid); 184895-34-9; 185069-15-2 Role: RCT (Reactant), RACT (Reactant or reagent) ([rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin deriv., synthesis)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1998:771624Other
Keywords:Antitumor agents ([rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin deriv., antitumor effect); Molecular structure ([rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin deriv., mol. structure); fluorophenyl ethylendiamine cyclobutane carboxylatoplatinum synthesis anticancer; carboplatin deriv anticancer
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:5478
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