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Characterization of the nuclear import of the human CHD4–NuRD complex

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Hoffmeister, Helen ; Holzinger, Simon ; Dürr, Marie-Sofie ; Bruckmann, Astrid ; Schindler, Susann G. ; Gröbner-Ferreira, Regina ; Depping, Reinhard ; Längst, Gernot
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Date of publication of this fulltext: 19 Jan 2024 13:52


Chromatin remodeling enzymes form large multiprotein complexes that play central roles in regulating access to the genome. Here, we characterize the nuclear import of the human CHD4 protein. We show that CHD4 enters the nucleus by means of several importin-α proteins (1, 5, 6 and 7), but independently of importin β1. Importin α1 directly interacts with a monopartite ‘KRKR’-motif in the N-terminus ...


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