Characterization of the nuclear import of the human CHD4–NuRD complex

URN to cite this document:: urn:nbn:de:bvb:355-epub-553713
DOI to cite this document:: 10.5283/epub.55371

Hoffmeister, Helen ; Holzinger, Simon

; Dürr, Marie-Sofie ; Bruckmann, Astrid ; Schindler, Susann G. ; Gröbner-Ferreira, Regina ; Depping, Reinhard ; Längst, Gernot

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Jan 2024 13:52

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Abstract

Chromatin remodeling enzymes form large multiprotein complexes that play central roles in regulating access to the genome. Here, we characterize the nuclear import of the human CHD4 protein. We show that CHD4 enters the nucleus by means of several importin-alpha proteins (1, 5, 6 and 7), but independently of importin beta 1. Importin alpha 1 directly interacts with a monopartite 'KRKR'-motif in ...