Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-568861
DOI to cite this document:: 10.5283/epub.56886

Artunc, Ferruh

; Bohnert, Bernhard N.

; Schneider, Jonas C. ; Staudner, Tobias ; Sure, Florian ; Ilyaskin, Alexandr V. ; Wörn, Matthias ; Essigke, Daniel

; Janessa, Andrea ; Nielsen, Nis V. ; Birkenfeld, Andreas L. ; Etscheid, Michael ; Haerteis, Silke

; Korbmacher, Christoph ; Kanse, Sandip M.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Feb 2024 12:41

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Abstract

Proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases is thought to contribute to renal sodium retention in nephrotic syndrome. However, the identity of the responsible proteases remains elusive. This study evaluated factor VII activating protease (FSAP) as a candidate in this context. We analyzed FSAP in the urine of patients with nephrotic ...