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Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice

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Artunc, Ferruh ; Bohnert, Bernhard N. ; Schneider, Jonas C. ; Staudner, Tobias ; Sure, Florian ; Ilyaskin, Alexandr V. ; Wörn, Matthias ; Essigke, Daniel ; Janessa, Andrea ; Nielsen, Nis V. ; Birkenfeld, Andreas L. ; Etscheid, Michael ; Haerteis, Silke ; Korbmacher, Christoph ; Kanse, Sandip M.
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Date of publication of this fulltext: 29 Feb 2024 12:41


Proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases is thought to contribute to renal sodium retention in nephrotic syndrome. However, the identity of the responsible proteases remains elusive. This study evaluated factor VII activating protease (FSAP) as a candidate in this context. We analyzed FSAP in the urine of patients with nephrotic ...


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