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Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

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Winkler, René ; Mägdefrau, Ann-Sophie ; Piskor, Eva-Maria ; Kleemann, Markus ; Beyer, Mandy ; Linke, Kevin ; Hansen, Lisa ; Schaffer, Anna-Maria ; Hoffmann, Marina E. ; Poepsel, Simon ; Heyd, Florian ; Beli, Petra ; Möröy, Tarik ; Mahboobi, Siavosh ; Krämer, Oliver H. ; Kosan, Christian
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Feb 2024 13:01


Overexpression of MYC is a genuine cancer driver in lymphomas and related to poor prognosis. However, therapeutic targeting of the transcription factor MYC remains challenging. Here, we show that inhibition of the histone deacetylase 6 (HDAC6) using the HDAC6 inhibitor Marbostat-100 (M-100) reduces oncogenic MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced aggressive B-cell ...


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