Introduction:
Treating major depressive disorder (MDD) with transcranial direct
current stimulation (tDCS) devices at home has various logistic advantages
compared to tDCS treatment in the clinic. However, preliminary (controlled)
studies showed side effects such as skin lesions and difficulties in the
implementation of home-based tDCS. Thus, more data are needed regarding
the feasibility and possible disadvantages of home-based tDCS.

Methods:
Ten outpatients (23–69 years) with an acute depressive episode were
included for this one-arm feasibility study testing home-based tDCS. All patients self-administered prefrontal tDCS (2 mA, 20 min, anodal left, cathodal right) at home on 30 consecutive working days supported by video consultations. Correct implementation of the home-based treatment was analyzed with tDCS recordings. Feasibility was examined by treatment compliance. For additional analyses of effectiveness, three depression scores were used: Hamilton depression rating scale (HDRS-21), Major Depression Inventory (MDI), and the subscale depression of the Depression-Anxiety-Stress Scale (DASS). Furthermore, usability was measured with the user experience questionnaire (UEQ). Tolerability was analyzed by the number of reported adverse events (AEs).

Results:
Eight patients did not stick to the protocol. AEs were minimal. Four
patients responded to the home treatment according to the MDI. Usability was
judged positive by the patients.

Conclusions:
Regular video consultations or other safety concepts are
recommended regardless of the number of video sessions actually conducted.
Home-based tDCS seems to be safe and handy in our feasibility study, warranting further investigation.