Epithelial Anoctamins

URN to cite this document:: urn:nbn:de:bvb:355-epub-583973
DOI to cite this document:: 10.5283/epub.58397

Schreiber, Rainer ; Ousingsawat, Jiraporn ; Kunzelmann, Karl

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Jun 2024 08:55

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Abstract

When activated by increase in intracellular Ca2+, anoctamins (TMEM16 proteins) operate as phospholipid scramblases and as ion channels. Anoctamin 1 (ANO1) is the Ca2+-activated epithelial anion-selective channel that is coexpressed together with the abundant scramblase ANO6 and additional intracellular anoctamins. In salivary and pancreatic glands, ANO1 is tightly packed in the apical membrane ...