Conditional Cell-Penetrating Peptide Exposure as Selective Nanoparticle Uptake Signal

URN to cite this document:: urn:nbn:de:bvb:355-epub-592547
DOI to cite this document:: 10.5283/epub.59254

Walter, Melanie ; Bresinsky, Merlin ; Zimmer, Oliver

; Pockes, Steffen

; Goepferich, Achim

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 24 Sep 2024 07:48

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Abstract

A major bottleneck diminishing the therapeutic efficacy of various drugs is that only small proportions of the administered dose reach the site of action. One promising approach to increase the drug amount in the target tissue is the delivery via nanoparticles (NPs) modified with ligands of cell surface receptors for the selective identification of target cells. However, since receptor binding ...