The Panama Canal was officially opened on 15 August 1914. At this point, the United States had been the builder of a difficult and controversial project for ten years and was to be the operator of the most important link between the Atlantic and the Pacific. To do this, it first helped Panama to independence, immediately annexing the canal zone. Thus, the construction of the canal is a classic lesson in colonial, (inter-)national politics and its interdependencies in the early twentieth century. At the same time, Panama was a fairly widespread topic of US popular music. This article investigates the effects of politics on cultural life, using the example of popular music referring to Panama. Applying a postcolonial approach, it will study the musical ways in which the United States constructed its pseudo-colony Panama as an Other in order to exercise power there and continue to form its own national identity.