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Journal or Publication Title: | Nature Genetics | ||||
Publisher: | NATURE PUBLISHING GROUP | ||||
Place of Publication: | NEW YORK | ||||
Volume: | 42 | ||||
Number of Issue or Book Chapter: | 11 | ||||
Page Range: | pp. 937-948 | ||||
Date: | 2010 | ||||
Institutions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
Identification Number: |
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Keywords: | GENOME-WIDE ASSOCIATION; GASTRIC-INHIBITORY POLYPEPTIDE; COMMON VARIANTS; EARLY-ONSET; FTO GENE; FAT MASS; OBESITY; GLUCOSE; METAANALYSIS; WEIGHT; | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 65644 |
Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci ...

Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Metadata last modified: 25 Jun 2025 06:22