Asymmetric Migratory Tsuji–Wacker Oxidation Enables the Enantioselective Synthesis of Hetero- and Isosteric Diarylmethanes

URN to cite this document:: urn:nbn:de:bvb:355-epub-746508
DOI to cite this document:: 10.5283/epub.74650

Frank, Eduard

; Park, Sooyoung

; Harrer, Elias

; Flügel, Jana L. ; Fischer, Marcel ; Nuernberger, Patrick

; Rehbein, Julia

; Breder, Alexander

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Jan 2025 08:39

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Abstract

Diarylmethanes play, in part, a pivotal role in the design of highly potent, chiral, nonracemic drugs whose bioactivity is typically affected by the substitution pattern of their arene units. In this context, certain arenes such as para-substituted benzenes or unsubstituted heteroarenes cause particular synthetic challenges, since such isosteric residues at the central methane carbon atom are ...