Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies

URN to cite this document:: urn:nbn:de:bvb:355-epub-748014
DOI to cite this document:: 10.5283/epub.74801

Bresinsky, Melanie ; Goepferich, Achim

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Jan 2025 07:42

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Abstract

The utilization of targeted nanoparticles as a selective drug delivery system is a powerful tool to increase the amount of active substance reaching the target site. This can increase therapeutic efficacy while reducing adverse drug effects. However, nanoparticles face several challenges: upon injection, the immediate adhesion of plasma proteins may mask targeting ligands, thereby diminishing the ...