MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

URN to cite this document:: urn:nbn:de:bvb:355-epub-767081
DOI to cite this document:: 10.5283/epub.76708

Guetter, Severin ; König, Courtney ; Koerkel-Qu, Huiqin ; Markiewicz, Aleksandra ; Scheitler, Sebastian ; Katzer, Marie ; Berneburg, Mark

; Renner, Philipp ; Cucuruz, Beatrix ; Guttenberger, Leonhard ; Naimer, Veronika ; Weidele, Kathrin ; Treitschke, Steffi ; Werno, Christian ; Jaser, Hanna ; Bargmann, Tonia ; Braun, Armin ; Weber, Florian

; Evert, Katja

; Rochwarger, Alexander ; Schürch, Christian M. ; Limm, Katharina

; Oefner, Peter J.

; Rachel, Reinhard

; Baumann, Felix ; Warfsmann, Jens ; Schmidleithner, Lisa

; Guetter, Kathrin ; Mohammadi, Parvaneh ; Ulmer, Anja ; Haferkamp, Sebastian

; Klein, Christoph A.

; Werner-Klein, Melanie

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 May 2025 11:37

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Abstract

To investigate the early, poorly understood events driving metastatic progression, we searched for the earliest detectable disseminated cancer cells (DCCs), also often referred to as disseminated tumor cells (DTCs), in sentinel lymph node (SLN) biopsies of 492 patients with stage I–III melanoma. Using micromanipulator-assisted isolation of rare DCCs, single-cell mRNA and DNA sequencing, ...