A probiotic approach identifies a Treg-centred immunoregulation via modulation of gut microbiota metabolites in people with multiple sclerosis and healthy individuals

URN to cite this document:: urn:nbn:de:bvb:355-epub-767535
DOI to cite this document:: 10.5283/epub.76753

Träger, Constantin ; Kaiser, Maria ; Freudenstein, David ; Heckscher, Simon ; Dettmer, Katja

; Oefner, Peter J.

; Liebisch, Gerhard

; Hiergeist, Andreas

; Gessner, André

; Lee, De-Hyung ; Angstwurm, Klemens

; Linker, Ralf A.

; Haase, Stefanie

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 04 Jun 2025 04:50

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Abstract

Background Modulation of the gut microbiota composition has been suggested as a potential disease modifying therapy in immune-mediated diseases such as multiple sclerosis (MS). However, a conclusive mechanism linking gut microbiota modulation to peripheral immune responses has remained elusive so far. Methods In this exploratory cohort study, people with MS (pwMS) and healthy controls (HC) ...