Microbiota-derived metabolites: Key modulators of cancer immunotherapies

URN to cite this document:: urn:nbn:de:bvb:355-epub-775327
DOI to cite this document:: 10.5283/epub.77532

Perl, Markus ; Fante, Matthias A.

; Herfeld, Konstantin ; Scherer, Julian N. ; Poeck, Hendrik

; Thiele Orberg, Erik

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Aug 2025 05:35

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Abstract

The human gut microbiome shapes local and systemic immune responses and influences cancer immunotherapy outcomes. Microbial metabolites, including short-chain and branched-chain fatty acids, bile acids, tryptophan derivatives, and others, influence anti-tumor immunity by modulating immune cells, tumor growth, and the tumor microenvironment. These metabolites impact the efficacy of immune ...