Confidence Intervals for Adaptive Trial Designs II: Case Study and Practical Guidance

URN to cite this document:: urn:nbn:de:bvb:355-epub-777093
DOI to cite this document:: 10.5283/epub.77709

Robertson, David S. ; Burnett, Thomas ; Choodari‐Oskooei, Babak ; Dimairo, Munya ; Grayling, Michael ; Pallmann, Philip ; Jaki, Thomas

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Date of publication of this fulltext: 22 Sep 2025 04:47

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Abstract

In adaptive clinical trials, the conventional confidence interval (CI) for a treatment effect is prone to undesirable properties such as undercoverage and potential inconsistency with the final hypothesis testing decision. Accordingly, as is stated in recent regulatory guidance on adaptive designs, there is the need for caution in the interpretation of CIs constructed during and after an adaptive ...