Adding experimental treatment arms to multi‐arm multi‐stage platform trials in progress

URN to cite this document:: urn:nbn:de:bvb:355-epub-777749
DOI to cite this document:: 10.5283/epub.77774

Burnett, Thomas ; König, Franz ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Sep 2025 07:29

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Abstract

Multi-arm multi-stage (MAMS) platform trials efficiently compare several treatments with a common control arm. Crucially MAMS designs allow for adjustment for multiplicity if required. If for example, the active treatment arms in a clinical trial relate to different dose levels or different routes of administration of a drug, the strict control of the family-wise error rate (FWER) is paramount. ...