The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

URN to cite this document:: urn:nbn:de:bvb:355-epub-780728
DOI to cite this document:: 10.5283/epub.78072

Göttert, Sascha ; Thiele Orberg, Erik

; Fan, Kaiji ; Heinrich, Paul

; Matthe, Diana M. ; Khalid, Omer ; Klostermeier, Lena ; Suriano, Chiara ; Strieder, Nicholas

; Gebhard, Claudia

; Vonbrunn, Eva ; Mamilos, Andreas

; Hirsch, Daniela ; Meedt, Elisabeth ; Kleigrewe, Karin ; Hiergeist, Andreas

; Schwarz, Alix ; Gläsner, Joachim ; Ghimire, Sakhila ; Joachim, Laura ; Voll, Florian ; Neuhaus, Klaus ; Janssen, Klaus-Peter ; Perl, Markus ; Pielmeier, Franziska ; Ruland, Jürgen ; Kreutz, Marina

; Weber, Daniela ; Schmidl, Christian

; Köhler, Natalie ; Tschurtschenthaler, Markus ; Hoffmann, Petra ; Edinger, Matthias

; Wolff, Daniel

; Bassermann, Florian ; Rehli, Michael

; Haller, Dirk ; Evert, Matthias ; Hildner, Kai ; Büttner-Herold, Maike ; Herr, Wolfgang ; Gessner, André

; Heidegger, Simon ; Holler, Ernst

; Poeck, Hendrik

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Nov 2025 07:50

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Abstract

Changes in the intestinal microbiome and microbiota-derived metabolites predict clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we report that desaminotyrosine (DAT), a product of bacterial flavonoid metabolism, correlates with improved overall survival and reduced relapse rates in patients receiving allo-HSCT. In preclinical mouse models, treatment ...