Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-783296
DOI to cite this document:: 10.5283/epub.78329

Babl, Nathalie

; Voll, Florian ; Martowicz, Agnieszka ; Bruss, Christina ; Maddaloni, Marianna ; Schmidl, Christian

; Rehli, Michael

; Loipfinger, Stefan ; Strieder, Nicholas

; Gebhard, Claudia

; Hoffmann, Petra ; Singh, Sukh M. ; Sala-Hojman, Ada ; Ferretti, Roberta ; Matos, Carina

; Simon, Malte

; Brummer, Christina ; Schnell, Annette

; Hofbauer, Joshua ; Decking, Sonja-Maria ; Hau, Peter

; Vollmann-Zwerenz, Arabel ; Dettmer, Katja

; Oefner, Peter J.

; Althammer, Michael ; Laufs, Johanna ; Friedl, Sarah ; Heinrich, Timo ; Herhaus, Christian ; Evert, Katja

; Mayr, Roman

; Afonso, Julieta ; Baltazar, Fatima ; Herr, Wolfgang ; Siska, Peter J.

; Renner, Kathrin

; Kreutz, Marina

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Dec 2025 05:31

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Abstract

Paradoxically, immune cell infiltration correlates with worse prognosis in renal cell carcinoma (RCC) patients, with tumor-associated myeloid cells playing a key role in tumor progression. However, little is known about factors driving their polarization. Here, we investigated the link between RCC-related glycolysis, hypoxia-inducible factor (HIF)1α-associated myeloid inflammation, and patient ...