Mayer, Matthias (2002) Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen. PhD, Universität Regensburg.
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Abstract (German)
Etliche Versuche wurden unternommen, fluoreszente Liganden als Alternative zu Radioliganden für Rezeptorbindungsstudien einzusetzen. Diese Methodik ist problematisch, wenn die Rezeptoren wie im Falle der G-Protein-gekoppelten Rezeptoren (GPCR´s) in ihrer natürlichen Umgebung, d. h. in Membranen oder in intakten Zellen untersucht werden müssen, da sich aufgrund der Autofluoreszenz ein geringes ...
Translation of the abstract (English)
Many attempts have been made to use fluorescent ligands as an alternative to radioligands for studies of receptors. This approach is hampered especially when receptors are to be investi-gated in their natural environment, i.e. in membranes or in intact cells as in case of g-protein coupled receptors (GPCR), due to a low signal-to-noise ratio resulting from autofluorescence. This problem can be ...
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| Item type: | Thesis of the University of Regensburg (PhD) |
|---|---|
| Date: | 15 May 2002 |
| Referee: | Prof. Dr. Armin Buschauer |
| Date of exam: | 22 April 2002 |
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Keywords: | Chemie , Fluorimetrie , fluorimetrisch , G-Protein-gekoppelter Rezeptor , Assay , Wirkstoff , Test , fluorimetric , G Protein-coupled receptor , assay |
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences |
| Status: | Published |
| Refereed: | Yes, this version has been refereed |
| Created at the University of Regensburg: | Yes |
| Item ID: | 9916 |
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