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Untersuchungen zur Funktion und Regulation des Tight Junction Moleküls Claudin-1 in der Brusttumorgenese

URN to cite this document: urn:nbn:de:bvb:355-opus-3547

Macek, Robert (2004) Untersuchungen zur Funktion und Regulation des Tight Junction Moleküls Claudin-1 in der Brusttumorgenese. PhD, Universität Regensburg

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Abstract (German)

Integrale Membranproteine der Claudin-Familie stellen die funktionellen Hauptkomponenten des Tight Junction Komplexes in normalen epithelialen und endothelialen Geweben dar. In ontogenetisch unterschiedlichen, epithelialen Tumoren wurden jedoch abberante Tight Junction Strukturen sowie eine dysregulierte Expression und Membranlokalisation Tight Junction assoziierter Proteine nachgewiesen. Dies ...

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Translation of the abstract (English)

Integral membrane proteins of the claudin family are the major structural components of tight junctions (TJ) in normal epithelial and endothelial tissues. However, in several ontogenetically different epithelial tumors abberant TJ structures as well as dysregulated expression and/or membrane localization of TJ associated proteins has been identified. These data gave rise to hypothesize that loss ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:6 December 2004
Referee:Hans-Robert (Prof. Dr. Dr.) Kalbitzer
Date of exam:5 February 2004
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Keywords:Onkologie , Nährstoffversorgung , Brustkrebs , Cytologie , Tight Junctions , Claudin-1 , Brusttumorgenese , RAR/RXR Rezeptoren , Chromatinkondensation , Claudin-1 , Tight Junctions , breast tumorigenesis , RAR/RXR receptors , chromatin condensation
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Oct 2009 15:37
Last Modified:13 Mar 2014 11:24
Item ID:10241
Owner Only: item control page
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