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Die Rolle des CD137-/CD137-Ligand-Systems in der anti-Tumor-Immunantwort

URN to cite this document: urn:nbn:de:bvb:355-opus-4523

Wittmann, Margarethe (2005) Die Rolle des CD137-/CD137-Ligand-Systems in der anti-Tumor-Immunantwort. PhD, Universität Regensburg

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Abstract (German)

Das CD137-/CD137-Ligand-System spielt in der Regulation von anti-Tumor-Immunantworten eine wichtige Rolle. In dieser Arbeit wurden zu ersten Mal die Auswirkungen der Expression von mCD137 auf Tumorzellen untersucht. Das Screening von Lymphozyten-Proben eines CLL-Patientenkollektivs ergab, daß die RNA für mCD137 in den stimulierten Zellen aller daraufhin untersuchten Patienten exprimiert wurde. ...

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Translation of the abstract (English)

The CD137-/CD137-ligand-system plays an important role in the regulation of anti-tumor immune responses. This work investigates the effect of expression of CD137 by tumor cells. Screening of lymphocyte samples of B-CLL-patients reveals that mCD137-RNA is expressed in stimulated cells of all screened persons. The expression of the membrane bound CD137-protein (mCD137) was shown by FACS analysis ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:13 February 2005
Referee:Hans-Robert (Prof. Dr. Dr.) Kalbitzer
Date of exam:2 February 2004
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Keywords:Tumorhemmung , Tumorimmunologie , Tumor , Lymphom , Krebs <Medizin> , B-Lymphozyt-Tumor , Antigen CD137 , Chronisch-lymphatische Leukämie , Cytolyse , Apoptosis , Antikörper , Signaltransduktion , Ligand <Biochemie> , Wirkstoff-Rezeptor-Bindung , Ligand , B-CLL , ILA , bidirektionale Signaltransduktion , anti-Tumor-Immunantwort , TNFR-Proteinfamilie , ILA , B-CLL , anti-tumor response , TNFR
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 06:57
Last Modified:13 Mar 2014 11:27
Item ID:10286
Owner Only: item control page
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