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Stimulation of Vgamma9/Vdelta2 T lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate

Amslinger, Sabine and Hecht, Stefan and Rohdich, Felix and Eisenreich, Wolfgang and Adam, Petra and Bacher, Adelbert and Bauer, Stefan (2007) Stimulation of Vgamma9/Vdelta2 T lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. Immunobiology 212 (1), pp. 47-55.

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Abstract

(E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate, a recently discovered intermediate in the deoxyxylulose phosphate pathway of isoprenoid biosynthesis, has been shown to act as a potent immunomodulator. In cultures of human peripheral blood mononuclear cells from eight non-related donors, the compound stimulated the proliferation of Vγ9/Vδ2 T lymphocytes with a median EC50 of 70 pM when 10 U/ml of ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1016/j.imbio.2006.08.003 DOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Dr. Sabine Amslinger
Deposited On:24 Nov 2009 14:52
Last Modified:05 Nov 2012 08:05
Item ID:11062
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