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Platelets induce monocyte differentiation in serum-free coculture

Ammon, C. and Kreutz, M. and Rehli, M. and Krause, S. W. and Andreesen, Reinhard (1998) Platelets induce monocyte differentiation in serum-free coculture. Journal of leukocyte biology 63 (4), pp. 469-76.

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Abstract

Terminal maturation of blood monocytes (MO) in vitro and in vivo into macrophages (MAC) occurs as a result of interactions with various cell types. To characterize some of the cell-cell connections that may be important for MO differentiation we cocultured human MO with lymphocytes and/or with platelets. We found that intact platelets strongly promoted MO maturation under serum-free conditions as ...

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Item Type:Article
Date:1998
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
9544577PubMed ID
Classification:
NotationType
Antibodies/pharmacologyMESH
Blood Platelets/physiologyMESH
Cell Differentiation/drug effectsMESH
Cells, CulturedMESH
Coculture TechniquesMESH
Culture Media, Serum-FreeMESH
Enzyme-Linked Immunosorbent AssayMESH
HumansMESH
Lymphocytes/physiologyMESH
Membrane Lipids/physiologyMESH
Membrane Proteins/physiologyMESH
Monocytes/physiologyMESH
Platelet-Derived Growth Factor/pharmacologyMESH
Transforming Growth Factor beta/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:35
Last Modified:15 Apr 2010 05:35
Item ID:14321
Owner Only: item control page
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