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Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent

Jeschke, M. G. and Richter, G. and Herndon, D. N. and Geissler, E. K. and Hartl, M. and Hofstädter, Ferdinand and Jauch, K. W. and Perez-Polo, J. R. (2001) Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent. Gene therapy 8 (23), pp. 1777-1784.

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Abstract

It is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we tested the hypothesis that nonviral liposomal gene delivery also displays this characteristic. We chose two different growth factors, keratinocyte growth factor (KGF) and insulin-like growth factor-I (IGF-I) CMV-driven transfecting constructs ...

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Item Type:Article
Date:2001
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
11803397PubMed ID
10.1038/sj.gt.3301589DOI
Classification:
NotationType
AnimalsMESH
ApoptosisMESH
Burns/therapyMESH
Cell DivisionMESH
Collagen/metabolismMESH
DNA, Complementary/geneticsMESH
Dose-Response Relationship, DrugMESH
Fibroblast Growth Factor 7MESH
Fibroblast Growth Factors/metabolismMESH
Gene Therapy/methodsMESH
Gene Transfer TechniquesMESH
Insulin-Like Growth Factor I/metabolismMESH
LiposomesMESH
MaleMESH
RatsMESH
Rats, Sprague-DawleyMESH
Skin/pathologyMESH
TransfectionMESH
Wound HealingMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:53
Last Modified:18 Jun 2010 08:53
Item ID:15400
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