Jeschke, M. G. and Richter, G. and Herndon, D. N. and Geissler, E. K. and Hartl, M. and Hofstädter, Ferdinand and Jauch, K. W. and Perez-Polo, J. R. (2001) Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent. Gene therapy 8 (23), pp. 1777-1784.
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It is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we tested the hypothesis that nonviral liposomal gene delivery also displays this characteristic. We chose two different growth factors, keratinocyte growth factor (KGF) and insulin-like growth factor-I (IGF-I) CMV-driven transfecting constructs ...
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|Institutions:||Medicine > Lehrstuhl für Pathologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||18 Jun 2010 08:53|
|Last Modified:||18 Jun 2010 08:53|