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Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers

Grepmeier, Ulrike and Dietmaier, Wolfgang and Merk, Johannes and Wild, Peter J. and Obermann, Ellen C. and Pfeifer, Michael and Hofstaedter, Ferdinand and Hartmann, Arndt and Woenckhaus, Matthias (2005) Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers. International journal of oncology 27 (2), pp. 481-488.

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Abstract

Most lung cancer is attributed to long-term smoking. In order to define chromosomal regions with an accumulation of smoking-related early molecular damage, we applied 15 microsatellite markers at 8 chromosomal regions (2q35-q36, 3p21.3, 3p14.2, 3p25, 10q11.2, 11p14-15, 12p13.1-p12.3 and 12q14) in an allelotyping study. We studied samples of 42 patients with primary non-small cell lung cancer ...

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Item Type:Article
Date:2005
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
16010431PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Bronchi/cytologyMESH
Carcinoma, Non-Small-Cell Lung/pathologyMESH
Chromosome DeletionMESH
Chromosomes, Human, Pair 11/geneticsMESH
Chromosomes, Human, Pair 12/geneticsMESH
Chromosomes, Human, Pair 2/geneticsMESH
Chromosomes, Human, Pair 3/geneticsMESH
Epithelial Cells/metabolismMESH
FemaleMESH
HumansMESH
Loss of HeterozygosityMESH
Lung Neoplasms/pathologyMESH
MaleMESH
Microsatellite RepeatsMESH
Middle AgedMESH
Smoking/adverse effectsMESH
Time FactorsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:21
Last Modified:18 Jun 2010 08:21
Item ID:15428
Owner Only: item control page
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