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The use of 3-D cultures for high-throughput screening: the multicellular spheroid model

Kunz-Schughart, Leoni A. and Freyer, James P. and Hofstaedter, Ferdinand and Ebner, Reinhard (2004) The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. Journal of biomolecular screening 9 (4), pp. 273-285.

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Abstract

Over the past few years, establishment and adaptation of cell-based assays for drug development and testing has become an important topic in high-throughput screening (HTS). Most new assays are designed to rapidly detect specific cellular effects reflecting action at various targets. However, although more complex than cell-free biochemical test systems, HTS assays using monolayer or suspension ...

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Item Type:Article
Date:2004
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
15191644PubMed ID
10.1177/1087057104265040DOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Drug Evaluation, Preclinical/methodsMESH
Drug Screening Assays, Antitumor/methodsMESH
HumansMESH
Models, BiologicalMESH
Spheroids, Cellular/drug effectsMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:22 Jun 2010 10:00
Last Modified:22 Jun 2010 10:00
Item ID:15508
Owner Only: item control page
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