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New cytotoxic prenylated isoflavonoids from Bituminaria morisiana

Cottiglia, Filippo and Casu, Laura and Bonsignore, Leonardo and Casu, Mariano and Floris, Costantino and Leonti, Marco and Gertsch, Juerg and Heilmann, Jörg (2005) New cytotoxic prenylated isoflavonoids from Bituminaria morisiana. Planta medica 71 (3), pp. 254-260.

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Abstract

Using cytotoxicity against KB cancer cells as a lead, bioguided-fractionation of the petroleum ether and Et acetate exts. of Bituminaria morisiana leaves led to the isolation of two new pterocarpans, namely 3,9-dihydroxy-4-(3,3-dimethylallyl) [6aR,11aR]-pterocarpan, 3-hydroxy-4-(3,3-dimethylallyl)-4'',5''-dehydropyrano[8,9:2'',3''][6aR,11aR]-pterocarpan and one new isoflavone identified as ...

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Item Type:Article
Date:2005
Additional information (public):CAN 143:109067 1-6 Pharmacology 479-13-0P (Coumestrol); 486-66-8P (Daidzein); 5768-44-5P (Pseudoisopsoralen); 119269-74-8P (Erybraedin C); 135384-00-8P (8-Prenyldaidzein); 161099-44-1P (Bidwillon C); 622368-03-0P (Bitucarpin A); 857254-94-5P (3,9-Dihydroxy-4-(3,3-dimethylallyl) [6aR,11aR]-pterocarpan); 857254-97-8P; 857349-91-8P Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (cytotoxic prenylated isoflavonoids from Bituminaria morisiana)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2005:284810Other
Keywords:Antitumor agents Human Leukemia Psoralea morisiana (cytotoxic prenylated isoflavonoids from Bituminaria morisiana) Isoflavonoids Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (cytotoxic prenylated isoflavonoids Flavonoids Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (pterocarpans cytotoxic prenylated isoflavonoids from Bituminaria morisiana) antitumor prenylated isoflavonoid Bituminaria isolation leukemia
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 12:44
Last Modified:18 Oct 2010 12:44
Item ID:17223
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