Andus, T. and Heinrich, P. C. and Bauer, J. and Tran-Thi, T. A. and Decker, K. and Männel, Daniela N. and Northoff, H.
Discrimination of hepatocyte-stimulating activity from human recombinant tumor necrosis factor alpha.
European journal of immunology 17 (8), pp. 1193-1197.
The involvement of tumor necrosis factor alpha (TNF alpha) in the regulation of acute-phase protein synthesis is currently under discussion. In this study the effect of human recombinant TNF alpha on the regulation of the 4 acute-phase proteins alpha 2-macroglobulin, albumin, alpha 1-proteinase inhibitor and alpha 1-acute-phase globulin was investigated in rat hepatocyte primary cultures. No changes in synthesis of any of the 4 proteins were observed. However, an acute-phase response similar to that in vivo could be generated by conditioned media from human monocytes containing natural TNF alpha. This response remained unchanged after neutralizing TNF alpha activity by the addition of a specific antibody to TNF alpha. It is concluded that the hepatocyte-stimulating activity synthesized by human monocytes is different from TNF alpha.
|Institutions:|| Medicine > Lehrstuhl für Immunologie|
|Tumor Necrosis Factor-alpha||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Jun 2011 08:14|
|Last Modified:||22 Oct 2012 09:48|