Bürgermeister, Jutta and Paper, Dietrich H. and Vogl, Horst and Linhardt, Robert J. and Franz, Gerhard (2002) LaPSvS1, a (1→3)-β-galactan sulfate and its effect on angiogenesis in vivo and in vitro. Carbohydrate research 337 (16), pp. 1459-1466.
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LaPSvS1, a highly sulfated branched (1→3)-β-galactan was prepared from the arabino-galactan from Larix decidua Miller by partial hydrolysis and subsequent sulfation with SO3-pyridine in DMF. The molecular weight was analyzed by GPC and the sulfate content was determined by ion chromatography. LaPSvS1 exhibited good antiangiogenic and antiinflammatory effects in two different modifications of the known CAM-assay. In vitro results obtained in the FGF-2-trypsin-assay and in fluorospectrometric experiments revealed that LaPSvS1 interacts with the fibroblast growth factor 2 system. This interaction is correlated with the in vivo effect of LaPSvS1 on FGF-2 induced angiogenesis.
A highly sulfated branched (1→3)-β-galactan (LaPSvS1) exhibits good antiangiogenic and antiinflammatory effects in CAM-assays. In vitro results reveal that LaPSvS1 interacts with the FGF-2 system correlating with the in vivo effect of LaPSvS1 on FGF-2 induced angiogenesis.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||21 Nov 2011 10:29|
|Last Modified:||29 Nov 2011 06:59|