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Characterisation of a laminarin sulphate which inhibits basic fibroblast growth factor binding and endothelial cell proliferation

Hoffmann, R. and Paper, D. H. and Donaldson, J. and Alban, S. and Franz, Gerhard (1995) Characterisation of a laminarin sulphate which inhibits basic fibroblast growth factor binding and endothelial cell proliferation. Journal of cell science 108, Pt. 1, pp. 3591-3598.

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Abstract

We have evaluated a series of laminarin sulphates with different degrees of sulphation (0.3-2.3) as antagonists of basic fibroblast growth factor (bFGF) and as inhibitors of the bFGF-dependent endothelial cell line FBHE. Inhibition of binding of bFGF by the laminarin sulphates increased with increasing degree of sulphation. Binding of bFGF to low affinity sites on BHK cells was inhibited more ...

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Item Type:Article
Date:1995
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz
Identification Number:
ValueType
8586670PubMed ID
Classification:
NotationType
AnimalsMESH
Anticoagulants/pharmacologyMESH
Antineoplastic Agents/pharmacologyMESH
CattleMESH
Cell Division/physiologyMESH
Cell Line/cytologyMESH
DNA/biosynthesisMESH
Endothelium/cytologyMESH
Fibroblast Growth Factor 2/metabolismMESH
Myocardium/cytologyMESH
Polysaccharides/metabolismMESH
Polysaccharides, Bacterial/pharmacologyMESH
Protein Binding/physiologyMESH
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:30 Nov 2011 08:52
Last Modified:30 Nov 2011 08:52
Item ID:22801
Owner Only: item control page
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