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Development and evaluation of multiplex and high-throughput SNP analysis for the ABCA1 gene

URN to cite this document:
urn:nbn:de:bvb:355-opus-3701
Probst, Mario C. O.
Date of publication of this fulltext: 13 Apr 2004 15:34


Abstract (English)

The main focus of this work was to develop high-throughput and multiplex assays for the fast and efficient analysis of sequence variations in the gene coding for the ATP-binding cassette transporter 1 (ABCA1), which has recently been identified as the main regulator of plasma HDL cholesterol. Intensive literature and data base research was performed to library all known sequence variations in ...

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Translation of the abstract (German)

Im Mittelpunkt dieser Arbeit stand die Entwicklung von Hochdurchsatz- und Multiplex- Assays für die schnelle und effiziente Analyse von Sequenzvariationen am Modellsystem des ATP-bindenden Cassetten Transporter A1 (ABCA1)-Gens, das als wichtigster Regulator von HDL Cholesterin im Plasma identifiziert wurde. Zunächst wurden in einer intensiven Literatur- und Datenbank-Recherche alle für dieses Gen ...

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