E-LDL and Ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human Macrophages

DOI to cite this document:: 10.5283/epub.1022

Grandl, Margot ; Maa Bared, Salim ; Liebisch, Gerhard ; Werner, Tobias ; Barlage, Stefan ; Schmitz, Gerd

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

Atherosclerosis is characterized by the generation of lipid-loaded macrophage-derived foam cells. To study the effect of different types of atherogenic lipoproteins, human macrophages were loaded with enzymatically degraded low density lipoprotein (E-LDL) or oxidized LDL (Ox-LDL). Cellular cholesterol content was increased by E-LDL, whereas Ox-LDL increased the ceramide content. Cell surface ...