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E-LDL and Ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human Macrophages

Grandl, Margot ; Bared, Salim Maa ; Liebisch, Gerhard ; Werner, Tobias ; Barlage, Stefan ; Schmitz, Gerd
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Date of publication of this fulltext: 05 Aug 2009 13:25


Abstract

Atherosclerosis is characterized by the generation of lipid-loaded macrophage-derived foam cells. To study the effect of different types of atherogenic lipoproteins, human macrophages were loaded with enzymatically degraded low density lipoprotein (E-LDL) or oxidized LDL (Ox-LDL). Cellular cholesterol content was increased by E-LDL, whereas Ox-LDL increased the ceramide content. Cell surface ...

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