High density lipoprotein modulates platelet function

DOI to cite this document:: 10.5283/epub.1023

Barlage, Stefan ; Boettcher, Dorothee ; Boettcher, Alfred ; Dada, Ashraf ; Schmitz, Gerd

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

BACKGROUND: Platelet activation by atherogenic lipoproteins can be antagonized by high density lipoprotein (HDL), probably via interaction with the ATP-binding cassette transporter A1 (ABCA1). METHODS: ABCA1 expression and its association with cholesterol rich membrane domains was analyzed by mRNA and Western blot analysis. HDL effects on platelet receptor clustering were analyzed by flow ...