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Untersuchungen zum Einsatz von small interfering RNAs gegen epidermal growth factor receptor in humanen Gliomzellen

URN to cite this document:
urn:nbn:de:bvb:355-opus-4392
Vollmann, Arabel
Date of publication of this fulltext: 07 Dec 2004 15:37


Abstract (German)

Humane maligne Gliome stellen die häufigste Form primärer Hirntumore des Erwachsenenalters dar. Ihre anatomische Lokalisation, die Infiltration des umgebenden gesunden Gehirngewebes und die Unterdrückung einer gegen den Tumor gerichteten Immunantwort tragen zu ihrem hochgradig aggressivem Phänotyp bei. Trotz intensiver Bemühungen, die neurochirurgischen, radiologischen und chemotherapeutischen ...

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Translation of the abstract (English)

Malignant glioma represent the most common primary brain tumors in the adult. Their anatomical localization, the infiltration of the surrounding healthy brain parenchyma and the suppression of a tumor-directed immune response contribute to their highly aggressive phenotype. Despite extensive efforts to improve surgery, radiology and chemotherapy, the median survival for patients with glioblastoma ...

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