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Untersuchungen zur Funktion und Regulation des Tight Junction Moleküls Claudin-1 in der Brusttumorgenese

URN to cite this document:
urn:nbn:de:bvb:355-opus-3547
Macek, Robert
Date of publication of this fulltext: 07 Dec 2004 15:37


Abstract (German)

Integrale Membranproteine der Claudin-Familie stellen die funktionellen Hauptkomponenten des Tight Junction Komplexes in normalen epithelialen und endothelialen Geweben dar. In ontogenetisch unterschiedlichen, epithelialen Tumoren wurden jedoch abberante Tight Junction Strukturen sowie eine dysregulierte Expression und Membranlokalisation Tight Junction assoziierter Proteine nachgewiesen. Dies ...

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Translation of the abstract (English)

Integral membrane proteins of the claudin family are the major structural components of tight junctions (TJ) in normal epithelial and endothelial tissues. However, in several ontogenetically different epithelial tumors abberant TJ structures as well as dysregulated expression and/or membrane localization of TJ associated proteins has been identified. These data gave rise to hypothesize that loss ...

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