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Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages
Ugocsai, Peter, Barlage, Stefan, Dada, Ashraf and Schmitz, Gerd (2006) Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages. Cytometry. Part A : the journal of the International Society for Analytical Cytology 69 (3), pp. 203-205.Date of publication of this fulltext: 05 Aug 2009 13:25
Article
DOI to cite this document: 10.5283/epub.1025
Abstract
Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased ...
Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased availability of HbHp complexes triggers the upregulation of surface CD163, and also results in a dose-dependent secretion of IL-6 and IL-10.
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Details
| Item type | Article | ||||||
| Journal or Publication Title | Cytometry. Part A : the journal of the International Society for Analytical Cytology | ||||||
| Volume: | 69 | ||||||
|---|---|---|---|---|---|---|---|
| Number of Issue or Book Chapter: | 3 | ||||||
| Page Range: | pp. 203-205 | ||||||
| Date | March 2006 | ||||||
| Institutions | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin | ||||||
| Identification Number |
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| Keywords | CD163; heme oxygenase-1; inflammatory cytokines | ||||||
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine | ||||||
| Status | Published | ||||||
| Refereed | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg | Yes | ||||||
| Item ID | 1025 |
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