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Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages
Ugocsai, Peter, Barlage, Stefan, Dada, Ashraf und Schmitz, Gerd (2006) Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages. Cytometry. Part A : the journal of the International Society for Analytical Cytology 69 (3), S. 203-205.Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:25
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DOI zum Zitieren dieses Dokuments: 10.5283/epub.1025
Zusammenfassung
Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased ...
Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased availability of HbHp complexes triggers the upregulation of surface CD163, and also results in a dose-dependent secretion of IL-6 and IL-10.
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| Dokumentenart | Artikel | ||||||
| Titel eines Journals oder einer Zeitschrift | Cytometry. Part A : the journal of the International Society for Analytical Cytology | ||||||
| Band: | 69 | ||||||
|---|---|---|---|---|---|---|---|
| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 | ||||||
| Seitenbereich: | S. 203-205 | ||||||
| Datum | März 2006 | ||||||
| Institutionen | Medizin > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin | ||||||
| Identifikationsnummer |
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| Stichwörter / Keywords | CD163; heme oxygenase-1; inflammatory cytokines | ||||||
| Dewey-Dezimal-Klassifikation | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||||
| Status | Veröffentlicht | ||||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||||
| An der Universität Regensburg entstanden | Ja | ||||||
| Dokumenten-ID | 1025 |
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