Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages

DOI to cite this document:: 10.5283/epub.1025

Ugocsai, Peter ; Barlage, Stefan ; Dada, Ashraf ; Schmitz, Gerd

PDF
(164kB) - Repository staff only

Date of publication of this fulltext: 05 Aug 2009 13:25

Alternative links to fulltext:Pubmed DOI Publisher

Details

Export bibliographical data

Abstract

Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased ...