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Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages

Ugocsai, Peter, Barlage, Stefan, Dada, Ashraf and Schmitz, Gerd (2006) Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages. Cytometry. Part A : the journal of the International Society for Analytical Cytology 69 (3), pp. 203-205.

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Other URL: http://dx.doi.org/10.1002/cyto.a.20235


Abstract

Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased ...

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Item type:Article
Date:March 2006
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
ValueType
16479607PubMed ID
10.1002/cyto.a.20235DOI
Keywords:CD163; heme oxygenase-1; inflammatory cytokines
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:1025
Owner only: item control page

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