Ezetimib influences the expression of raft-associated antigens in human monocytes

DOI to cite this document:: 10.5283/epub.1027

Orsó, Evelyn ; Werner, Tobias ; Wolf, Zsuzsanna ; Bandulik, Sascha ; Kramer, Werner ; Schmitz, Gerd

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

Aminopeptidase N (CD13) was recently identified as a molecular target of the cholesterol absorption inhibitor Ezetimib. Regarding that CD13 is expressed in lipid rafts of monocytic cells, we have investigated whether Ezetimib influences raft function in these cells. Expression of raft-associated antigens (CD11b, CD13, CD14, CD16, CD36, and CD64) was followed by flow cytometry and/or immunoblot in ...