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Die Rolle des CD137-/CD137-Ligand-Systems in der anti-Tumor-Immunantwort

URN to cite this document:
urn:nbn:de:bvb:355-opus-4523
DOI to cite this document:
10.5283/epub.10286
Wittmann, Margarethe
Date of publication of this fulltext: 14 Feb 2005 06:57


Abstract (German)

Das CD137-/CD137-Ligand-System spielt in der Regulation von anti-Tumor-Immunantworten eine wichtige Rolle. In dieser Arbeit wurden zu ersten Mal die Auswirkungen der Expression von mCD137 auf Tumorzellen untersucht. Das Screening von Lymphozyten-Proben eines CLL-Patientenkollektivs ergab, daß die RNA für mCD137 in den stimulierten Zellen aller daraufhin untersuchten Patienten exprimiert wurde. ...

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Translation of the abstract (English)

The CD137-/CD137-ligand-system plays an important role in the regulation of anti-tumor immune responses. This work investigates the effect of expression of CD137 by tumor cells. Screening of lymphocyte samples of B-CLL-patients reveals that mCD137-RNA is expressed in stimulated cells of all screened persons. The expression of the membrane bound CD137-protein (mCD137) was shown by FACS analysis ...

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