Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro

DOI to cite this document:: 10.5283/epub.1031

Blank, Christian ; Kuball, Juergen ; Voelkl, Simon ; Wiendl, Heinz

; Becker, Bernd ; Walter, Bernhard ; Majdic, Otto ; Gajewski, Thomas F. ; Theobald, Mathias ; Andreesen, Reinhard ; Mackensen, Andreas

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

Human tumors frequently escape immune destruction, despite the presence of cyototoxic T cells (CTL) recognizing tumor-associated antigens (TAA). We have previously shown that programmed death ligand-1 (PD-L1), a recently identified ligand of the B7 superfamily, is expressed on murine tumors and can inhibit antitumor immune responses. To evaluate the clinical relevance of our animal model ...