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Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro

Blank, Christian, Kuball, Juergen, Voelkl, Simon, Wiendl, Heinz, Becker, Bernd, Walter, Bernhard, Majdic, Otto, Gajewski, Thomas F, Theobald, Mathias, Andreesen, Reinhard and Mackensen, Andreas (2006) Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. International journal of cancer. Journal international du cancer 119 (2), pp. 317-327.

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Other URL: http://dx.doi.org/10.1002/ijc.21775


Abstract

Human tumors frequently escape immune destruction, despite the presence of cytotoxic T cells (CTL) recognizing tumor-associated antigens (TAA). We have previously shown that programmed death ligand-1 (PD-L1), a recently identified ligand of the B7 superfamily, is expressed on murine tumors and can inhibit antitumor immune responses. To evaluate the clinical relevance of our animal model findings, ...

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Item type:Article
Date:15 July 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
16482562PubMed ID
10.1002/ijc.21775DOI
Keywords:RCC; PD-L1; PD-1; B7-H1; melanoma
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:1031
Owner only: item control page

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