The promotion of oriented axonal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogels

DOI to cite this document:: 10.5283/epub.1038

Prang, Peter ; Müller, Rainer ; Eljaouhari, Ahmed ; Heckmann, Klaus ; Kunz, Werner ; Weber, Thomas ; Faber, Cornelius ; Vroemen, Maurice ; Bogdahn, Ulrich ; Weidner, Norbert

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

Appropriate target reinnervation and functional recovery after spinal cord injury depend on longitudinally directed regrowth of transected axons. To assess the capacity to promote directed axon regeneration, alginate-based highly anisotropic capillary hydrogels (ACH) were introduced into an axon outgrowth assay in vitro and adult rat spinal cord lesions in vivo. In an entorhino-hippocampal slice ...