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Polyethylenimine-based nucleic acid delivery

URN to cite this document:
urn:nbn:de:bvb:355-opus-5911
Breunig, Miriam
Date of publication of this fulltext: 23 Nov 2006 07:41


Abstract (English)

With recent advances in molecular biology and the sequencing of the human genome, nucleic acids are expected to engage a pivotal position in the development of novel therapeutic concepts. Although viral vectors are very effective and are capable of many of the required tasks for efficient gene transfer, their broad use is limited by severe safety risks [1,2]. Therefore, this work focused on the ...

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Translation of the abstract (German)

Aufgrund der jüngsten Fortschritte in der Molekularbiologie und der abgeschlossenen Sequenzierung des menschlichen Genoms, erhofft man sich, dass Nukleinsäuren eine Schlüsselposition in der Entwicklung neuer therapeutischer Konzepte einnehmen. Obwohl Viren sehr effektive Transporter darstellen und besonders geeignet sind, viele der an sie gestellten Anforderungen für einen effizienten Gentransfer ...

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