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Analysen zum onkogenen Potenzial des E1B-55K-Proteins von Adenovirus Typ 5

Härtl, Barbara (2006) Analysen zum onkogenen Potenzial des E1B-55K-Proteins von Adenovirus Typ 5. PhD, Universität Regensburg.

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Date of publication of this fulltext: 13 Oct 2006 07:51

Abstract (German)

Das 55-kDa Genprodukt der frühen Region 1B (E1B-55K) von Adenovirus Serotyp 5 (Ad5) ist ein multifunktionelles Phosphoprotein, das eine zentrale Rolle im Ad5-vermittelten Transformationsvorgang primärer Zellen einnimmt. Den onkogenen Aktivitäten des E1B-Proteins liegen verschiedene Wirkmechanismen zugrunde. An erster Stelle steht dabei die Inaktivierung des zellulären Tumorsuppressorproteins p53 ...


Translation of the abstract (English)

The 55K product from adenovirus type 5 (Ad5) early region 1B (E1B-55K) belongs to a group of adenoviral regulatory proteins that are individually capable of cooperating with Ad early region 1A (E1A) to oncogenically transform primary rodent cells in culture. A large body of evidence indicates that the transforming potential of Ad5 E1B-55K correlates with its ability to act as a direct ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:12 October 2006
Referee:Thomas (PD Dr.) Dobner
Date of exam:27 April 2006
Institutions:Biology, Preclinical Medicine
Keywords:Adenovirus 5 , Maligne Transformation , Protein p53 , Genregulation , E1B-55K , NES , PML-NBs , Mre11 , E1B-55K , NES , PML-NBs , Mre11
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10470
Owner only: item control page


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