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Genetic analysis of the Sall transcription factor family in murine development

Elling, Ulrich (2006) Genetic analysis of the Sall transcription factor family in murine development. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 Nov 2006 07:51

Abstract (English)

Spalt (sal)-like proteins are transcription factors that are described for nematodes, shrimp, insects and multiple chordata analyzed till date. Mutations in genes of the spalt like transcription factor family have been shown to manifest in phenotypic aberrations in several model organisms. Moreover, humans carrying mutations in spalt like genes suffer from various developmental defects. A deeper ...


Translation of the abstract (German)

Spalt Proteine bilden eine Familie von Transkriptionsfaktoren, die von Caenorhabdits elegans über Drosophila melanogaster bis hin zu Vertebraten konserviert sind. In Säugetiergenomen findet man jeweils vier Gene, die als Spalt-like (SALL1 bis SALL4)bezeichnet werden. Mutationen in SALL1 und SALL4 verursachen im Menschen Townes-Brocks-Syndrom (TBS) beziehungsweise Okihiro-/Duane Radial Ray-Syndrom ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:5 November 2006
Referee:Stephan (Prof. Dr.) Schneuwly
Date of exam:22 March 2006
Additional Information (public):PNAS, in print
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Keywords:Entwicklungsbiologie , Maus , Stammzelle , Knockout <Molekulargenetik> , Embryonalentwicklung , Genexpression , Transkriptionsfaktor , , transcription factor , ES cells , stem cells , Sall4 , TBS
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10476
Owner only: item control page


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