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Asymmetric synthesis and histamine receptor activity of new H1-receptor agonists and conformationally restricted H3-receptor antagonists

URN to cite this document:
urn:nbn:de:bvb:355-opus-6673
Patil, Rameshwar
Date of publication of this fulltext: 13 Jun 2007 08:10


Abstract (English)

Histamine H1-Receptor (H1R) Ligands: Developing highly potent and selective histamine H1-receptor (H1R) agonists has been an arduous task for several decades. Highly potent and selective H1R agonists are in demand for pharmacological and molecular investigation. Recently, the histaprodifens, a family of 2-(3,3-diphenylpropyl)-substituted histamine derivatives, have been established as new class ...

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Translation of the abstract (German)

Histamin H1-Rezeptor (H1R) Liganden: Die Entwicklung hoch potenter und selektiver H1-Rezeptor (H1R) Agonisten war lange Zeit eine sehr schwierige Aufgabe. Vor kurzem konnten die Histaprodifene, eine Familie von 2-(3,3-Diphenylpropyl)-substituierten Histamin-Derivaten, als neuartige selektive und potente H1R Agonisten identifiziert werden. Auf der Basis dieser neuen Ergebnisse wurden in der ...

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